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A "Case Study in Science"
Should Dinosaurs Be "Cloned" From Ancient DNA?
by CM Soja (Department of Geology) & D Huerta (Science Library)
Colgate University
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PART I: INTRODUCTION
The year is 2020. You have pursued various careers in science, business, medicine, etc. in
the 11 or so years since you graduated from Colgate. Because of your knowledge about
evolution and the dinosaur fossil record, you've been asked to participate in a landmark
case that will decide if dinosaurs should be cloned from ancient DNA. Experts with various
backgrounds and interests - and knowledge about dinosaurs and the evolutionary process -
are being assembled to aid in the decision-making process. You
and your colleagues will be deciding if extinct species should be brought back to life.
You don't have long to decide either - new cloning techniques are being tested around the
world and the possibility of resurrecting extinct species may soon be within our grasp.
Keller Securities has offered to sponsor your participation, so you and other Colgate
alums have been brought together for a debriefing of the situation. Here is what you learn:
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Termites in 30 million-year-old amber and laboratory breakdowns of their DNA patterns
[Smithsonian, 1993, v. 23 (23), p. 29]
used with kind permission of the photographer, Henry Groskinsky
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"Many of you remember from the evolution class you took at Colgate many years ago
that dinosaurs were the dominant forms of life on land for more than 100 million years.
Dinosaurs lived on all continents in a wide spectrum of environments from the poles to the tropics.
All of the evidence suggests that dinosaurs were successful, complex animals well adapted
to conditions on Earth. In fact, many scientists believe that the evolutionary potential
of mammals was suppressed throughout the entire Mesozoic because of the supremacy and
dominance of the dinosaurs. Only during Pangea break-up and after dinosaurs were removed
from the scene did mammals undergo an evolutionary radiation to occupy many of the niches
left vacant as a result of the Cretaceous/Tertiary mass extinction.
In the decades since the asteroid hypothesis was first proposed by Walter Alvarez and others
to explain the sudden demise of the dinosaurs 66 million years ago, scientists have continued
to accumulate incontrovertible evidence that the extinction of the dinosaurs was caused by an
impacting asteroid from outer space. Substantiation of this theory proves that dinosaurs
became extinct NOT because of "bad genes" or a lack of adaptability to natural changes taking
place on Earth but because of random bad luck caused by a horrifying extraterrestrial event
that wiped out a significant percentage of Earth's species at the end of the Mesozoic.
With recent advances in molecular biology, we now have at our disposal the technology that
will enable us to reverse this unfortunate set of circumstances for the dinosaurs. Sources
of dinosaur DNA have been identified at several (secret) sites around the world. Available
technology will enable us to extract the fossilized DNA from dinosaur remains, purify it,
concentrate or amplify it, and replicate it before implanting the dinosaur DNA into donor
eggs from closely related species. Here is our chance to undo the after-effects of the
asteroid and return to Earth closely managed members of the dominant life forms that preceded
us in time.
Since the evolution of Homo sapiens in the past half million years, we have been
accused of
propagating a new mass extinction. Many scientists now believe that the so-called "Sixth
Extinction" began in the Pleistocene as recently as 50,000-100,000 years ago when humans as
hunters or disease vectors
began a worldwide decimation of megafauna (e.g., large-bodied mammals). Scientists from every
continent have expressed their growing concerns that this mass extinction event continues to
accelerate today, rivaling the Mesozoic mass extinction in the scope and intensity of species
extinctions around the globe. With new cloning techniques, we now have within our grasp the
opportunity to reverse the deadly decline of global biodiversity and reinstate to Earth critical
members of global ecosystems that existed here only a short time ago, geologically speaking.
Your decision will determine the ultimate fate of the dinosaurs. Should they be doomed to
extinction forever or brought back to the Earth they should have inherited? You will have
several days to evaluate the situation and prepare a report that will enable the judges in this
case to reach a final decision. The latest information about scientific research on cloning
has been made available to you, including some discussion about human cloning. But remember,
this is a case about whether dinosaurs, not humans, should be cloned.
Thank you for your
participation in an historic case that will have global implications."
HERE'S THE SITUATION
You have several days before you and your colleagues must decide the fate of the dinosaurs before a
world audience anxious to know your decision. Before reaching any conclusions, however, you
need to understand more about the science of cloning; genetic engineering of ancient DNA; how to
develop a dinosaur embryo and successfully raise it to adulthood; animal husbandry issues related
to supporting a living, adult dinosaur under post-Mesozoic conditions; safety issues; ethical
issues, etc.
To facilitate court proceedings, each of you will serve either as a judge or
represent a particular specialty on one of two teams: one team will argue the case in support
of dinosaur cloning and the other will present arguments against dinosaur cloning.
Each team (either for or against cloning) will comprise six specialist types (investor,
paleontologist, etc.) who will present testimony to the Judges. Each specialist type
will be represented by several people, including one person who will act as "designated
hitter" at trial for that specialist group (see responsibility explained below).
ROLE ASSIGNMENTS
High Court Judges (8)
responsible for making final decision after hearing from two teams of specialists
Two Teams--
One For and the Other Against Dinosaur Cloning
each team comprises specialists who provide Judges with expert testimony as:
investors (6)#
paleontologists (5)
geneticists (5)
ethicists (5)
veterinarians (5)
civilians (6)#
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1 of each specialist type
will be a "designated
hitter"* at trial:
1 investor and 1 civilian will serve as "opener" and "closer"
(see below)
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Individual Specialist and Team Responsibilities
For the trial, each member of each specialist group (including the
"designated hitter," "opener" and "closer") prepares (individually) a one- to two-page (max),
double-spaced, typed report that is exceptionally well written, representing your
position using your own words and phrases and citing any references that you used.
It is ok to confer with your partners and teammates (not the judges), but do your
write-up on your own. Notice that under Grading Assessment,
points will be awarded
to those who show special creativity and develop exceptionally worthy or original
ideas based on research that either builds on or goes beyond the information provided
in each specialist page.
These reports become the basis for oral testimony given at trial. Be prepared with
your partners to present your case (5-6 minutes max! per specialist group) to the
Esteemed Judges using whatever creative, innovative, educational, but worthy means
you decide--but keep in mind that each team will have no more than 35 minutes to
present its entire case. #One investor will give
his/her 1 minute presentation to "open" the case, and
one civilian will give his/her 1 minute presentation to
"close" the case for the "for" and "against" teams.
*Also please note that
the "designated hitter" on each
team will not give a 1-2 minute presentation but rather will be responsible for
answering 2 questions from the Esteemed Judges, answering 1 question
from the opposing team's "designated hitter," and posing 1 question to the opposing
team's "designated hitter." Please be prepared to start the debate on time so that
we can accommodate everyone who will be giving testimony and can allow the judges
enough time to ask questions and reach a majority decision before court is adjourned.
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Because of the number of specialists who will be presenting a 1 minute
(max!) testimonial each,
Power Pt. or other computer-based presentations
are NOT permitted.
However, specialists ARE
encouraged to dress appropriately for their roles, teams can bring
placards or posters with
supporting graphics, etc. or engage in other educationally worthy
activities to bring a creative,
but non-disruptive flair to the proceedings.
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Judges' Responsibilities
The judges should approach their roles as highly educated, ultra objective, scrupulous
decision-makers.For the trial date, each judge should
prepare (individually) a one- to
two-page (max!), double-spaced, typed statement (as above) that is exceptionally well
written, indicating his/her position (for or against dinosaur cloning) before hearing
the depositions in class. It is ok to confer with your fellow judges, but do your write-up
on your own using your own words and phrases and citing any references that you used.
Notice that under Grading Assessment, points will be
awarded to those who show special
creativity and develop exceptionally worthy or original ideas based on research that
either builds on or goes beyond the information provided in each specialist page.
Judges, of course, should not engage in conversations with members of either team before
testimony is given.
Before the court session, judges should designate someone as "Chief Judge" and should
have predetermined how to call upon the specialists in an orderly, organized, and fair
fashion, allowing each team no more than 35 minutes to plead its case. Judges should
be prepared to pose 2 questions to the "designated hitter" for each specialist
group, and the Chief Judge should make sure that the "designated hitters" question each
other after each specialist group has given its testimony. Judges will have a chance to
confer with each other briefly after hearing all of the depositions and so will have the
opportunity to change their positions in response to particularly persuasive testimony
or argument. By the end of trial, the judges will announce a majority opinion about
whether to allow dinosaur cloning. Please be prepared to start trial on time so that
we can accommodate everyone who will be giving testimony and can allow the judges enough
time to ask questions and reach a decision before court is adjourned.
Grading Assessment
Your participation in this exercise will be worth 50 points total. My assessment of
your work will be as follows: 5 pts. for the presentation given by your group of
specialists (or judges) with an additional 3 pts. (max.) awarded for creativity; 5 pts.
for your individual presentation with an additional 2 pts. (max.) awarded for creativity;
35 pts. for your written report.
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Please note that the first two classes for Cloning I
and II are very important because roles will be assigned and class
will be devoted to collecting data and working with teammates.
Your full participation is
expected. Absences because of serious illness or a family emergency
will be excused if
I receive notification before class; points will be deducted for
any unexcused absences.
As you can well anticipate, judges and specialist teams will be depending
on all members to
contribute to the success of the debate.
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Your written report should follow the directions in the "responsibilities" sections
above and will be graded on both its scientific/educational content and presentation.
Good grammar and spelling as well as careful proofreading of a polished text will
definitely count in your favor! Points will be awarded to those who show special
creativity and develop exceptionally worthy or original ideas based on research
that either builds on or goes beyond the information provided in each specialist
page.
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Specialists should make sure that their group presentation
is coordinated so that members representing the same specialty (on the same team) do not duplicate
information being presented to the judges.
Late assignments will not be accepted. Please note in
particular that last-minute problems with computer disks, printers, internet access, etc., will be
inexcusable reasons for not having your written assignment completed on time. Please plan ahead to
avoid last-minute headaches!
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PROCEEDINGS SCHEDULE
Today, you'll begin working with your partners using computers and the web exercise so that you
can confer about the discussion questions posed in Part II of the exercise. Judges and specialists
should follow the directions in this web exercise, looking specifically at the page that refers
to their specialty in Part II. These pages will give starter ideas for an approach to take and
clues about how a person with that specialty might think. Be sure to check Parts I and II,
discussion questions, web links, and the cloning e-folder. Also there are helpful resources in the science
library, including journal articles, books, etc. as well as lots of opinion and news pieces on the
internet. Your textbooks will be helpful, too.
Please return to class at 10:55 today for a Q & A session.
Thursday, you'll see a video on dinosaurs that will give
interesting background information on
the topic you're debating and relate very well both to the discussion questions and to the
upcoming court session. After that, we'll have a week of
regular class meetings with time to clarify any remaining questions before we go to trial.
On the trial date, we'll hold court to decide the fate of the
dinosaurs. Please be prepared to
start the trial on time so that we can accommodate everyone who will be giving testimony and can
allow the judges enough time to ask questions and reach a majority decision before court is
adjourned.
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